產品介紹

倍他米鬆

【結構式】

BETAMETHASONE  CAS378-44-9

【中文別稱】16b-甲基-11b,17a,21-三羥基-9a-孕甾-1,4-二烯-3,20-二酮

【分子式】C28H37FO7【分子量】504.59  

【外觀性狀】

白色結晶性粉末。熔點231-234℃(分解)。無臭。醋酸倍他米鬆([987-24-6])亦為白色結晶性粉末,熔點205-208℃,微溶於丙醇、乙醇,極難溶於氯仿或乙醚,不溶於水,無臭。

【用途】

激素類藥。主要用於抗炎及抗過敏。適用於風濕性關節炎及各種皮膚病。倍他米鬆的作用同地塞米鬆,其抗炎作用比地塞米鬆、去炎鬆、氫化可的鬆強,副作用少。   

【激素類藥物】

倍他米鬆又稱培他美鬆、貝皮質醇、貝氟美鬆、培氟美鬆,屬於腎上腺皮質激素類藥物,為地塞米鬆的同分異構體,作用與潑尼鬆龍和地塞米鬆相同,具有抗炎、抗風濕、抗過敏和抑製免疫等多種藥理作用,抗炎作用較地塞米鬆、曲安西龍、氫化可的鬆等均強,可以減輕和防止組織對炎症的反應,消除局部非感染性炎症引起的發熱、發紅及腫脹,從而減輕炎症的表現,本品0.3mg的抗炎療效與地塞米鬆0.75mg、潑尼鬆5mg或可的鬆25mg相當。

倍他米鬆的鈉瀦留作用為氫化可的鬆的百倍以上,在原發性腎上腺皮質功能減退症中,可與糖皮質類固醇一起用於替代治療,防止或抑製細胞中介的免疫反應,延遲性的過敏反應,並減輕原發免疫反應的擴展,適用於低腎素低醛固酮綜合征和植物神經病變所致體位性低血壓等。

目前倍他米鬆還用於治療活動性風濕病、類風濕性關節炎、紅斑性狼瘡、嚴重支氣管哮喘、嚴重皮炎、急性白血病、過敏性皮炎、濕疹、神經性皮炎、脂溢性皮炎及瘙癢症和某些感染的綜合治療。

本品禁用於嚴重的精神病史,活動性十二指腸、胃潰瘍,新近胃腸吻合術後,較重的骨質疏鬆,明顯的糖尿病,嚴重的高血壓,未能用抗菌藥物控製的病毒、細菌、黴菌感染、血栓性靜脈炎、感染性皮膚病,如膿皰病、體癬、股癬等。

[Name] Betamethasone

[Structure]

[CAS] 378-44-9[Synonyms]

1,4-PREGNADIEN-9-ALPHA-FLUORO-16-BETA-METHYL-11-BETA[Molecular Formula]

C28H37FO7[Molecular Weight]

504.59[Appearance]White to Off-White Solid[mp ]235-237°C[Usage]Glucocorticoid

[CAS No.]378-44-9

[hormone drugs]

Betamethasone, belongs to adrenal corticosteroids, it is a isomer of dexamethasone , and the role of betamethasone is similiar to prednisolone and dexamethasone , it has anti-inflammatory, anti-rheumatic, anti-allergic and suppression of the immune and other pharmacological effects, its anti-inflammatory effect is stronger than dexamethasone, triamcinolone, hydrocortisone etc. , it can reduce and prevent tissue response to inflammation and eliminate heat, redness and swelling caused by local non-infectious inflammation, thereby reducing the performance of inflammation, anti-inflammatory effect of this product 0.3mg is equal to dexamethasone 0.75mg, prednisone 5mg or 25mg cortisone .

Betamethasone sodium retention effect is a hundred times more than hydrocortisone, in primary adrenal hypofunction, it can be used together with glucocorticoid for replacement therapy ,and it is used for preventing or inhibiting cell-mediated immune response, delaying allergic reactions and reducing the primary immune response expansion ,it is used for low renin and low aldosterone syndrome and autonomic neuropathy induced orthostatic hypotension.

Currently betamethasone is also used for the treatment of active rheumatoid arthritis, rheumatoid arthritis, lupus, severe bronchial asthma, severe dermatitis, acute leukemia, atopic dermatitis, eczema, neurodermatitis, seborrheic dermatitis, and pruritus and comprehensive treatment of certain infections.

The product is contraindicated in severe psychiatric history, active duodenal ulcer, recent gastrointestinal anastomosis, heavier osteoporosis, overt diabetes, severe hypertension, virus , bacterial, fungal infections which are failed to control by the use of antimicrobial agents , thrombophlebitis, skin infections, such as impetigo, tinea, jock itch and so on.

The above information is edited by the chemicalbook of Tian Ye.

[Chemical Properties]

White crystalline powder. Mp 231-234 deg.] C (decomposition). Odorless. Acetate Betamethasone ([987-24-6]) is also white crystalline powder, melting point 205-208 , slightly soluble in alcohol, ethanol, and very slightly soluble in chloroform or ether, insoluble in water, odorless.

[Uses]

Hormone drugs.It is mainly used for anti-inflammatory and anti-allergic. It is suitable for rheumatoid arthritis and various skin diseases. Betamethasone role is similiar to dexamethasone, its anti-inflammatory effect is stronger than dexamethasone, triamcinolone, hydrocortisone and it has few side effects.